Fresh analysis indicates that individuals who stop using new slimming jabs like semaglutide or tirzepatide can put back on reduced body mass at a significantly accelerated pace than those who stop traditional lifestyle programs.
Findings released in a leading medical journal demonstrates that while obese people often shed a large proportion of their total mass while using the jabs, the mass returns at an estimated rate of 0.8 kg per month once they quit.
"People using these medications must be aware of the potential of quick weight regain when the medication is stopped," warns expert Dr. Susan Jebb.
Such speed of recovery suggests a return to pre-treatment weight within about a year and a half.
Comparing Therapies
The analysis, which looked at 37 of studies involving thousands of participants, compared the results of GLP-1 agonists with other pills.
The team emphasize that people who shed pounds through lifestyle changes alone generally have a slower creep back—approximately 0.1 kg a month—once they finish.
Explaining the Rapid Rebound
Nutrition scientists propose the way of the drugs is key to understanding the heightened regain.
These medications copy a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Sustained high doses of the hormone concentrations far above than normal may cause the system to produce less of its own natural hormone, and could lessen responsiveness to its effects," explained Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication leads to appetite is uncontrolled, making excessive eating much more probable."
An Ongoing Disease?
The NHS suggest the injections for people with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts argue that, considering the likelihood of relapse, the therapy should be considered long-term.
This perspective is supported by pharmaceutical companies, who note that the findings "highlight the long-term nature of excess weight," akin to managing conditions like diabetes.
Patient Experiences
Users who have discontinued the medication report a powerful return of appetite.
"It felt as if something that goes on and I was suddenly extremely hungry," described an individual.
This difficulty is worsened if patients have not developed permanent dietary or behavioural modifications during therapy.
Significant Adoption
Survey data indicate that millions of people in the UK have used these injections in the past year, with demand being substantial.
- Use is higher among women compared to males.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than the NHS.
Finally, experts stress that while these medications are effective agents for weight loss, they are not a permanent solution and long-term success relies on ongoing behavioural support.
